.alpha.1-proteinase inhibitor human
.alpha.1-proteinase inhibitor human is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| glassia | Biologic Licensing Application | 2010-12-20 |
| prolastin-c | Biologic Licensing Application | 2009-10-31 |
| zemaira | Biologic Licensing Application | 2010-09-29 |
Indications
FDA
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Agency Specific
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Clinical
Clinical Trials
164 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alpha 1-antitrypsin deficiency | D019896 | — | E88.01 | 28 | 40 | 13 | 8 | 45 | 118 |
| Emphysema | D004646 | EFO_0000464 | J43 | 1 | 8 | 1 | 2 | 12 | 23 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 3 | 1 | 3 | 12 | 19 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 2 | — | 1 | — | 5 |
| Bronchiectasis | D001987 | — | J47 | — | — | — | 1 | 3 | 4 |
| Hemophilia b | D002836 | — | D67 | — | — | — | 1 | 1 | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | 1 | 2 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | 1 | — | 1 |
| Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | — | — | — | 1 | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | 1 | — | 1 |
Show 1 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary emphysema | D011656 | — | J43 | — | 4 | 5 | — | 10 | 18 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | 5 | 3 | — | 1 | 7 |
| Covid-19 | D000086382 | — | U07.1 | — | 2 | 1 | — | 2 | 5 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 2 | 2 | — | — | 2 |
| Job syndrome | D007589 | EFO_0003775 | D82.4 | — | 2 | 2 | — | — | 2 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | 2 | — | — | 10 | 12 |
| Obstructive lung diseases | D008173 | — | — | — | 1 | — | — | 11 | 12 |
| Fibrosis | D005355 | — | — | 1 | 1 | — | — | 7 | 9 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | 4 | — | — | 4 | 9 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 4 | 6 | — | — | — | 8 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 2 | 3 | — | — | 4 | 8 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | 3 | 4 |
| Inflammation | D007249 | MP_0001845 | — | 2 | 2 | — | — | 1 | 3 |
| Lung transplantation | D016040 | — | — | — | 1 | — | — | 1 | 2 |
| Kidney transplantation | D016030 | — | — | — | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromyelitis optica | D009471 | EFO_0004256 | G36.0 | 1 | — | — | — | — | 1 |
| Optic neuritis | D009902 | EFO_0007405 | H46 | 1 | — | — | — | — | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 1 | — | — | — | — | 1 |
| Coronavirus | D017934 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary fibrosis | D011658 | — | J84.10 | — | — | — | — | 4 | 4 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | — | — | — | 3 | 3 |
| Argininosuccinic aciduria | D056807 | — | — | — | — | — | — | 2 | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 2 | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 2 | 2 |
| Cholestasis | D002779 | — | K83.1 | — | — | — | — | 2 | 2 |
| Alagille syndrome | D016738 | EFO_0004151 | Q44.71 | — | — | — | — | 2 | 2 |
| Inborn genetic diseases | D030342 | EFO_0000508 | — | — | — | — | — | 2 | 2 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 1 | 1 |
Show 29 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | .alpha.1-proteinase inhibitor human |
| INN | _ |
| Description | .alpha.1-proteinase inhibitor human is a protein pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Protein |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297879 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | F43I396OIS (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Additional graphs summarizing 1,271 documents
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Safety
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Adverse Events
Top Adverse Reactions
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9,062 adverse events reported
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